Agent Organization
A team of specialized reasoning agents coordinated by a Chief Scientist. Each discovery run flows through five phases — from strategy to a ranked set of testable experiments — with an adversarial Skeptic and an Evidence grader guarding scientific quality.
Strategy
Decompose the objective into tractable questionsChief Scientist
0 act.Sets strategy & decomposes the objective
Translates the research objective into a set of specific, unanswered, computationally-tractable questions and coordinates the specialist agents.
Investigation
Specialists gather and reason over public evidenceLiterature Agent
0 act.Continuously reads the published record
Mines PubMed and curated literature for what is known, contested, and unresolved about the objective.
Genomics Agent
0 act.Analyzes mutations & expression
Examines HER2 mutation frequency, clinical significance, and co-alterations that shape resistance.
Protein Agent
0 act.Structures & mutation effects
Reasons over HER2 domain architecture and how specific mutations perturb conformation and binding interfaces.
Drug Agent
0 act.Compound interactions & docking
Assesses how approved HER2 therapeutics engage the target and which alterations blunt their binding.
Pathway Agent
0 act.Signaling-network analysis
Maps downstream and bypass signaling (PI3K/AKT, MAPK, HER3) that enables escape from HER2 blockade.
Synthesis
Design in-silico tests and assemble hypothesesSimulation Agent
0 act.In-silico computational experiments
Designs and interprets computational tests (mutation destabilization, docking deltas) against known data.
Critique
Adversarial review and evidence gradingSkeptic Agent
0 act.Tries to disprove every finding
Adversarially attacks each hypothesis: confounders, alternative explanations, contradicting evidence, and overreach.
Evidence Agent
0 act.Grades evidence quality
Scores the strength and quality of supporting and contradicting evidence for each surviving hypothesis.
Output
Convert survivors into testable experimentsExperiment Designer
0 act.Hands researchers testable candidates
Converts the highest-ranked hypotheses into concrete, prioritized laboratory and in-silico experiments.